Sonographic alteration of lenticular nucleus in focal task-specific dystonia of musicians.
Identifieur interne : 001283 ( Main/Exploration ); précédent : 001282; suivant : 001284Sonographic alteration of lenticular nucleus in focal task-specific dystonia of musicians.
Auteurs : Uwe Walter [Allemagne] ; Franziska Buttkus ; Reiner Benecke ; Annette Grossmann ; Dirk Dressler ; Eckart AltenmüllerSource :
- Neuro-degenerative diseases [ 1660-2862 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Corps strié, Dystonie.
- imagerie diagnostique : Corps strié, Dystonie.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Musique, Mâle, Échographie-doppler transcrânienne.
English descriptors
- KwdEn :
- MESH :
- diagnostic imaging : Corpus Striatum, Dystonia.
- pathology : Corpus Striatum, Dystonia.
- Adult, Female, Humans, Male, Middle Aged, Music, Ultrasonography, Doppler, Transcranial.
Abstract
BACKGROUND/AIMS
In distinct movement disorders, transcranial sonography detects alterations of deep brain structures with higher sensitivity than other neuroimaging methods. Lenticular nucleus hyperechogenicity on transcranial sonography, thought to be caused by increased local copper content, has been reported as a characteristic finding in primary spontaneous dystonia. Here, we wanted to find out whether deep brain structures are altered in task-specific dystonia.
METHODS
The frequency of sonographic brainstem and basal ganglia changes was studied in an investigator-blinded setting in 15 musicians with focal task-specific hand dystonia, 15 musicians without dystonia, and 15 age- and sex-matched nonmusicians without dystonia.
RESULTS
Lenticular nucleus hyperechogenicity was found in 12 musicians with task-specific dystonia, but only in 3 nondystonic musicians (Fisher's exact test, p = 0.001) and 2 nonmusicians (p < 0.001). The degree of lenticular nucleus hyperechogenicity in affected musicians correlated with age, but not with duration of music practice or duration of dystonia. In 2 of 3 affected musicians with normal echogenic lenticular nucleus, substantia nigra hyperechogenicity was found.
CONCLUSIONS
Our findings support the idea of a pathogenetic link between primary spontaneous and task-specific dystonia. Sonographic basal ganglia alteration might indicate a risk factor that in combination with extensive fine motor training promotes the manifestation of task-specific dystonia.
DOI: 10.1159/000330712
PubMed: 21912095
Affiliations:
Links toward previous steps (curation, corpus...)
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Benecke</name></author><author><name sortKey="Grossmann, Annette" sort="Grossmann, Annette" uniqKey="Grossmann A" first="Annette" last="Grossmann">Annette Grossmann</name></author><author><name sortKey="Dressler, Dirk" sort="Dressler, Dirk" uniqKey="Dressler D" first="Dirk" last="Dressler">Dirk Dressler</name></author><author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21912095</idno><idno type="pmid">21912095</idno><idno type="doi">10.1159/000330712</idno><idno type="wicri:Area/Main/Corpus">001409</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001409</idno><idno type="wicri:Area/Main/Curation">001409</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001409</idno><idno type="wicri:Area/Main/Exploration">001409</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sonographic alteration of lenticular nucleus in focal task-specific dystonia of musicians.</title><author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Rostock, Rostock, Germany. uwe.walter@med.uni-rostock.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Rostock, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Buttkus, Franziska" sort="Buttkus, Franziska" uniqKey="Buttkus F" first="Franziska" last="Buttkus">Franziska Buttkus</name></author><author><name sortKey="Benecke, Reiner" sort="Benecke, Reiner" uniqKey="Benecke R" first="Reiner" last="Benecke">Reiner Benecke</name></author><author><name sortKey="Grossmann, Annette" sort="Grossmann, Annette" uniqKey="Grossmann A" first="Annette" last="Grossmann">Annette Grossmann</name></author><author><name sortKey="Dressler, Dirk" sort="Dressler, Dirk" uniqKey="Dressler D" first="Dirk" last="Dressler">Dirk Dressler</name></author><author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name></author></analytic><series><title level="j">Neuro-degenerative diseases</title><idno type="eISSN">1660-2862</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Corpus Striatum (diagnostic imaging)</term><term>Corpus Striatum (pathology)</term><term>Dystonia (diagnostic imaging)</term><term>Dystonia (pathology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Music (MeSH)</term><term>Ultrasonography, Doppler, Transcranial (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Corps strié (anatomopathologie)</term><term>Corps strié (imagerie diagnostique)</term><term>Dystonie (anatomopathologie)</term><term>Dystonie (imagerie diagnostique)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Musique (MeSH)</term><term>Mâle (MeSH)</term><term>Échographie-doppler transcrânienne (MeSH)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps strié</term><term>Dystonie</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Corpus Striatum</term><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Corps strié</term><term>Dystonie</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Dystonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Music</term><term>Ultrasonography, Doppler, Transcranial</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Musique</term><term>Mâle</term><term>Échographie-doppler transcrânienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND/AIMS</b></p><p>In distinct movement disorders, transcranial sonography detects alterations of deep brain structures with higher sensitivity than other neuroimaging methods. Lenticular nucleus hyperechogenicity on transcranial sonography, thought to be caused by increased local copper content, has been reported as a characteristic finding in primary spontaneous dystonia. Here, we wanted to find out whether deep brain structures are altered in task-specific dystonia.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The frequency of sonographic brainstem and basal ganglia changes was studied in an investigator-blinded setting in 15 musicians with focal task-specific hand dystonia, 15 musicians without dystonia, and 15 age- and sex-matched nonmusicians without dystonia.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Lenticular nucleus hyperechogenicity was found in 12 musicians with task-specific dystonia, but only in 3 nondystonic musicians (Fisher's exact test, p = 0.001) and 2 nonmusicians (p < 0.001). The degree of lenticular nucleus hyperechogenicity in affected musicians correlated with age, but not with duration of music practice or duration of dystonia. In 2 of 3 affected musicians with normal echogenic lenticular nucleus, substantia nigra hyperechogenicity was found.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our findings support the idea of a pathogenetic link between primary spontaneous and task-specific dystonia. Sonographic basal ganglia alteration might indicate a risk factor that in combination with extensive fine motor training promotes the manifestation of task-specific dystonia.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21912095</PMID><DateCompleted><Year>2012</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1660-2862</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>2</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Neuro-degenerative diseases</Title><ISOAbbreviation>Neurodegener Dis</ISOAbbreviation></Journal><ArticleTitle>Sonographic alteration of lenticular nucleus in focal task-specific dystonia of musicians.</ArticleTitle><Pagination><MedlinePgn>99-103</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000330712</ELocationID><Abstract><AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">In distinct movement disorders, transcranial sonography detects alterations of deep brain structures with higher sensitivity than other neuroimaging methods. Lenticular nucleus hyperechogenicity on transcranial sonography, thought to be caused by increased local copper content, has been reported as a characteristic finding in primary spontaneous dystonia. Here, we wanted to find out whether deep brain structures are altered in task-specific dystonia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The frequency of sonographic brainstem and basal ganglia changes was studied in an investigator-blinded setting in 15 musicians with focal task-specific hand dystonia, 15 musicians without dystonia, and 15 age- and sex-matched nonmusicians without dystonia.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Lenticular nucleus hyperechogenicity was found in 12 musicians with task-specific dystonia, but only in 3 nondystonic musicians (Fisher's exact test, p = 0.001) and 2 nonmusicians (p < 0.001). The degree of lenticular nucleus hyperechogenicity in affected musicians correlated with age, but not with duration of music practice or duration of dystonia. In 2 of 3 affected musicians with normal echogenic lenticular nucleus, substantia nigra hyperechogenicity was found.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings support the idea of a pathogenetic link between primary spontaneous and task-specific dystonia. Sonographic basal ganglia alteration might indicate a risk factor that in combination with extensive fine motor training promotes the manifestation of task-specific dystonia.</AbstractText><CopyrightInformation>Copyright © 2011 S. Karger AG, Basel.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Walter</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Rostock, Rostock, Germany. uwe.walter@med.uni-rostock.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buttkus</LastName><ForeName>Franziska</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Benecke</LastName><ForeName>Reiner</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Grossmann</LastName><ForeName>Annette</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dressler</LastName><ForeName>Dirk</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Altenmüller</LastName><ForeName>Eckart</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>09</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Neurodegener Dis</MedlineTA><NlmUniqueID>101189034</NlmUniqueID><ISSNLinking>1660-2854</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004421" MajorTopicYN="N">Dystonia</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009146" MajorTopicYN="N">Music</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017585" MajorTopicYN="N">Ultrasonography, Doppler, Transcranial</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>05</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>07</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21912095</ArticleId><ArticleId IdType="pii">000330712</ArticleId><ArticleId IdType="doi">10.1159/000330712</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name><name sortKey="Benecke, Reiner" sort="Benecke, Reiner" uniqKey="Benecke R" first="Reiner" last="Benecke">Reiner Benecke</name><name sortKey="Buttkus, Franziska" sort="Buttkus, Franziska" uniqKey="Buttkus F" first="Franziska" last="Buttkus">Franziska Buttkus</name><name sortKey="Dressler, Dirk" sort="Dressler, Dirk" uniqKey="Dressler D" first="Dirk" last="Dressler">Dirk Dressler</name><name sortKey="Grossmann, Annette" sort="Grossmann, Annette" uniqKey="Grossmann A" first="Annette" last="Grossmann">Annette Grossmann</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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